I have the 5th pick in a 12 team league

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I have the 5th pick in a standard scoring league with the exception of PPR and a 3wr starting lineup. I'm going with Jackson in the 1st. My question is, do I go with someone like a Willie Parker or that type of RB in the second round or do I go with a top 5 WR. I'm really leaning towards best available at this point and just hope that I can land a decent RB in the 3rd round.

 

Thanks for any advice.