I am sitting Nicks and here is why,
I think if he plays it will force SF to put their top corner on him. He then will be strictly a decoy so other healthy receivers (if they have any) can go against lower tiered corners. Also, Nicks runs a lot of go routes, speed is a big part of his game. A possession type guy would not be as affected by a hammy problem, but I think Nicks will very limited.