(Assuming Mike Williams; Chargers). Great question. All 4 should produce consistent WR-2 numbers (sometimes better) in most weeks; there is much to like and very few negatives. Probably splitting hairs when ranking; guessing the season-ending winner(s) = throwing darts. Doug Orth's Big Board(s) are useful to make comparisons. For now, he has Lockett & Aiyuk in the Tier just above Williams & Kirk. For what it's worth, here is a destined-to-be-wrong stab in the dark.
1) Kirk. <--If all 4 of these WR's finish 'about the same' in most weeks or for the year (*assume: re-draft league) I'm picking the one I can get at lower ADP, thusly drafting a player I want in a higher round.
2) Lockett. Should catch half the td volume of DK, but maybe more targets/catches/volume in most weeks. The add of JSN helps free him up downfield for big plays.
3) Aiyuk. Year 3 WR; he seems poised to have a great season. Cautious that Purdy *loves* throwing to Deebo and there are many other weapons at 49'ers. Also concerned over the number of non-CMC pass plays to be called per game. Should think that the talent is there in spades...but opportunity may be a bit lower.
4) Williams. Might play on the best offense in the league this year. Might catch more td's than any of the other 4. Also the most likely to get hurt for 4-6 games, like he does most past seasons. Probably more huge, week-winning WR-1' games than any of the other 4 - and - the most week-losing <10-point games. Both fun & frustrating. Love trading this guy for a good RB after a few boom-games.