BTW theyve known Vicks, Sudafed, Dayquil do nothing since 1972

[JustinCharge 2,397]

the FDA just never bothered to try to get drug companies to take them off the shelves.  50 year scam.  nasal sprays work tho.

https://www.yahoo.com/lifestyle/decongestant-phenylephrine-doesnt-work-fda-panel-224134951.html

Decongestant found in Sudafed PE, Vicks Dayquil and others doesn’t work, FDA panel says. Here’s why and what you should use instead of phenylephrine.

Rebecca Corey

·Writer and Reporter

Wed, September 13, 2023 at 3:41 PM PDT·5 min read

The main ingredient in popular over-the-counter decongestant found in pharmacy aisles under familiar brands like Sudafed PE, Vicks DayQuil, Theraflu and others isn’t effective, according to advisers to the Food and Drug Administration.

After a two-day meeting, the panel of 16 experts unanimously concluded on Sept. 12 that the popular drug phenylephrine works no better than a placebo pill.

What is phenylephrine?

Phenylephrine is an over-the-counter drug that has been used for decades to relieve congestion and stuffy nose caused by allergies or colds, and purportedly works by reducing the swelling of blood vessels in the nasal passages.

The FDA advisory panel concluded that oral forms of phenylephrine are ineffective, but nasal sprays and drops containing phenylephrine weren’t under review and are still considered effective.

Phenylephrine has been available for so long — what changed?

In 2007, researchers at the University of Florida questioned the efficacy of phenylephrine decades after it had been "legacied" in for approval by an FDA review begun in 1972, but the FDA allowed it to stay on the market pending additional research. Those same University of Florida researchers again urged the FDA to remove phenylephrine products from shelves after recent studies showed they were no better than placebos at treating cold and allergy congestion.

“A lot of things have changed since 2007,” Dr. Zara Patel of Stanford Medicine, tells Yahoo Life. “Science has improved, the way in which we study medications has improved and even the outcome measures that we use to determine whether nasal congestion is getting better have improved.”

She adds that people shouldn’t be upset by this new update.

“This is just how science works. That’s the beauty of science — we can gather more, new, better data and allow that data to change our minds about something.”

Experts Yahoo Life spoke with said they weren’t surprised — and that many clinicians already avoided recommending phenylephrine to patients.

“We've known that for a long time,” Dr. J. Routt Reigart, chair of the American Academy of Pediatrics committee on drugs. “Most pediatricians do not intentionally prescribe phenylephrine-containing remedies.”

Why doesn’t it work?

When taken in oral form, phenylephrine is metabolized pretty quickly, so the amount that’s absorbed into the bloodstream ends up being less than 1% of what was originally ingested — which is not enough to be effective, experts concluded.

But if you’ve used phenylephrine at the recommended dosage in the past, you don’t need to worry. FDA advisers didn’t flag any new side effects or dangers when taken as directed.

“It’s not that anyone was put at risk, it’s just that it’s not effective,” Patel says. “I would say it’s more a waste of time [and] a waste of money.”

Why does phenylephrine seem to work for me?

If oral phenylephrine has been your go-to for congestion relief, you may be confused by news that it’s actually no better than a dummy pill. Experts say there could be some placebo effect at play — with patients experiencing some relief because of their belief in the power of the pill.

Patel says that if medications containing phenylephrine have helped you feel better in the past, it may have more to do with the other ingredients involved.

“Most of the time phenylephrine is being combined with other medications that help with other symptoms that people get with a cold or with allergies,” she says. “Any of your typical cold and sinus over the counter meds or allergy over the counter meds, they won't just have phenylephrine in them. They have phenylephrine plus maybe some mucus thinning medication, maybe some expectorant medication to help with coughing or a cough suppressant. There’s so many different types of medications that are typically combined in these generalized cold pills or allergy pills, and that really may be why they do feel some benefit.”

It’s also possible that people may have experienced some benefit from oral phenylephrine medications, but FDA advisers concluded that simply wasn’t the case for a majority of people.

“When we talk about safety and efficacy, we’re looking at averages,” Patel explains. “There are some people that are much more sensitive to medications, so it is possible that some people will have some effect at a lower dose than others. When we say something’s not effective, that means the majority of people that took that medicine did not find benefit. It doesn’t mean that a few people may not have.”

What happens next and what should I use instead?

If the FDA decides to follow the advisory panel’s recommendations, drugmakers may be required to remove oral phenylephrine medications from store shelves. But that process would likely take awhile, so we shouldn’t expect to see any immediate impact from the panel’s decision.

In the meantime, experts say there are plenty of options.

“There’s so many other products out there that really do work,” Dr. James Tracy, vice president of the American College of Allergy, Asthma and Immunology, tells Yahoo Life. “Almost all the nasal sprays, like nasal antihistamine sprays, they all work and they are also over-the-counter, but they don’t say ‘decongestant.’”

Pseudoephedrine is the most common oral decongestant alternative, but since it has potential for abuse, you’ll likely need to ask a pharmacist for help accessing it behind the counter. Some states also have limits per family on how much you can purchase, or may require you to show some form of ID.

In addition to topical steroid sprays and topical antihistamine sprays, which are safe and effective, phenylephrine is also still considered effective in nasal spray form — though Tracy warns it can be “habit-forming” if used regularly.

“You should only use those for two to three days at the most,” he says of phenylephrine nasal sprays. “There can be, definitely, a side effect of something we refer to as ‘rebound congestion’ [if overused], but they definitely work.”

For children suffering from allergies, Reigart says saline nose drops or first generation antihistamines such as Benadryl can be beneficial for congestion. But oftentimes, you can skip the meds.

“My recommendation for the usual cold or runny nose, if it’s not allergic, would be not to use anything,” Reigart says.

[weepaws 3,154]

Vick’s works very well 

[Thornton Melon 605]

1 minute ago, weepaws said:

Vick’s works very well 

The vapor rub does, for me anyway 

[Hawkeye21 2,381]

That stuff always helped when I needed it.  Nyquil is great for getting sleep.

[RLLD 4,143]

What if it were true.....that there were folks at the FDA......who's family members were being funnelled money from these companies.....would that be wrong?

[GutterBoy 2,898]

Let's just be clear here, as the title is misleading and the OP is a complete moron.

phenylephrine is the ingredient in question.  It is a decongestant, meaning it relieves nasal congestion, or is supposed to, because it doesn't work.  It's an ingredient in common cold and flu mediciine.

Years ago, before the Meth epidemic, the preferred decongestant was pseudoephedrine, which works fairly well.  After Heisenberg started buying up all the sudaphed to make meph, the govt cracked down, and manufacturers were forced to replace the good stuff with the crap.  This is why we can't have nice things.

You can still get pseudoephedrine but in limited quantities and on its own.

Those multi symptom cold medicines still work at other things, like runny nose, sneezing, fever reducer, cough suppressant, helping you sleep, etc.  But it won't help you get healthy faster, it just helps relieve symptoms.

[Twinsdad 53]

Definitely noticed the change in the Sudafed once they started putting the stuff that works behind the counter.  I stopped using that.  Dayquil seemed somewhat effective, but it could have been the other active ingredients.  Nyquil is the bomb for nighttime.

 

[tinfoil hat]This FDA panel got kickbacks from the nasal spray lobbyists[/tinfoil hat] 

[OldMaid 2,129]

24 minutes ago, Hawkeye21 said:

That stuff always helped when I needed it.  Nyquil is great for getting sleep.

NyQuil-The nighttime sniffling, sneezing, coughing, aching how the fock did I get my kitchen medicine.

 

[listen2me 23 1,825]

58 minutes ago, GutterBoy said:

But it won't help you get healthy faster, it just helps relieve symptoms.

No way!  Really?

Lol

[Cdub100 3,835]

Whisky and honey

[MTSkiBum 1,620]

The good Sudafed still works, but you need to ask the pharmacist for it.

[edjr 6,578]

1 hour ago, OldMaid said:

NyQuil-The nighttime sniffling, sneezing, coughing, aching how the fock did I get my kitchen medicine.

 

“how did I end up on my kitchen floor”

[TheNewGirl 1,347]

2 hours ago, GutterBoy said:

Let's just be clear here, as the title is misleading and the OP is a complete moron.

phenylephrine is the ingredient in question.  It is a decongestant, meaning it relieves nasal congestion, or is supposed to, because it doesn't work.  It's an ingredient in common cold and flu mediciine.

Years ago, before the Meth epidemic, the preferred decongestant was pseudoephedrine, which works fairly well.  After Heisenberg started buying up all the sudaphed to make meph, the govt cracked down, and manufacturers were forced to replace the good stuff with the crap.  This is why we can't have nice things.

You can still get pseudoephedrine but in limited quantities and on its own.

Those multi symptom cold medicines still work at other things, like runny nose, sneezing, fever reducer, cough suppressant, helping you sleep, etc.  But it won't help you get healthy faster, it just helps relieve symptoms.

OH NO!!! Not more MEPH!!!! We have enough already!

[JustinCharge 2,397]

2 hours ago, GutterBoy said:

Let's just be clear here, as the title is misleading and the OP is a complete moron.

phenylephrine is the ingredient in question.  It is a decongestant, meaning it relieves nasal congestion, or is supposed to, because it doesn't work.  It's an ingredient in common cold and flu mediciine.

Years ago, before the Meth epidemic, the preferred decongestant was pseudoephedrine, which works fairly well.  After Heisenberg started buying up all the sudaphed to make meph, the govt cracked down, and manufacturers were forced to replace the good stuff with the crap.  This is why we can't have nice things.

You can still get pseudoephedrine but in limited quantities and on its own.

Those multi symptom cold medicines still work at other things, like runny nose, sneezing, fever reducer, cough suppressant, helping you sleep, etc.  But it won't help you get healthy faster, it just helps relieve symptoms.

shut up they can read the article i linked if they want you moron.  i put it under spoilers so it doesnt clog the forum.  you dont have to regurgitate what it is in the article and post it FOCKING TWICE!

[GutterBoy 2,898]

Just now, TheNewGirl said:

OH NO!!! Not more MEPH!!!! We have enough already!

Good catch.

[GutterBoy 2,898]

1 minute ago, JustinCharge said:

shut up they can read the article i linked if they want you moron.  i put it under spoilers so it doesnt clog the forum.  you dont have to regurgitate what it is in the article and post it FOCKING TWICE!

The first 3 posts clearly show you misled the board, so I wanted to correct and clarify.  Sorry if you have a problem with clarity and factual data.  Stick to predicting nuclear war.

[JustinCharge 2,397]

3 minutes ago, GutterBoy said:

The first 3 posts clearly show you misled the board, so I wanted to correct and clarify.  Sorry if you have a problem with clarity and factual data.  Stick to predicting nuclear war.

i didnt mislead the board.  I LITERALLY linked the article explaining it.  moron.  there is nothing to correct.  stick to not loggin in.  at BEST you are being a grammar nazi.

[GutterBoy 2,898]

2 minutes ago, JustinCharge said:

i didnt mislead the board.  I LITERALLY linked the article explaining it.  moron.  there is nothing to correct.  stick to not loggin in.  at BEST you are being a grammar nazi.

Dayquil do nothing since 1972

 

Dayquil wasn't sold until 1992.

 

[JustinCharge 2,397]

Just now, GutterBoy said:

Dayquil do nothing since 1972

 

Dayquil wasn't sold until 1992.

 

again, stop it grammar nazi.  the article was posted for all to read.

are you this shitty towards misleading titles from the new york times and cnn?  fock no.   thanks for shitting on the forum today.

[OldMaid 2,129]

21 minutes ago, edjr said:

“how did I end up on my kitchen floor”

I also can’t remember which comedian used to do that bit. 

[edjr 6,578]

8 minutes ago, OldMaid said:

I also can’t remember which comedian used to do that bit. 

John Pinette

Id link it to YouTube if I wasn’t on an airplane

[MLCKAA 540]

5 minutes ago, edjr said:

John Pinette

Id link it to YouTube if I wasn’t on an airplane

Fat guy.  That’s what makes it funny.

[Pimpadeaux 2,404]

2 hours ago, Twinsdad said:

Definitely noticed the change in the Sudafed once they started putting the stuff that works behind the counter.  I stopped using that.  Dayquil seemed somewhat effective, but it could have been the other active ingredients.  Nyquil is the bomb for nighttime.

 

[tinfoil hat]This FDA panel got kickbacks from the nasal spray lobbyists[/tinfoil hat] 

Nyquil is the bomb. 

[Baker Boy 1,687]

3 hours ago, RLLD said:

What if it were true.....that there were folks at the FDA......who's family members were being funnelled money from these companies.....would that be wrong?

If a product works, you buy it again, if it doesn’t work, you don’t buy it again. funneling money is not going to help a product that doesn’t work.

[RLLD 4,143]

7 minutes ago, Baker Boy said:

If a product works, you buy it again, if it doesn’t work, you don’t buy it again. funneling money is not going to help a product that doesn’t work.

Hmmmm, not exactly.  Have you read up on how the Sacklers managed to get Oxy approved?

[TBayXXXVII 2,482]

2 hours ago, listen2me 23 said:

No way!  Really?

Lol

You beat me to it.

[TBayXXXVII 2,482]

1 hour ago, MLCKAA said:

Fat guy.  That’s what makes it funny.

A real shame he passed away.  He was hilarious.

[BudBro 173]

Budesonide stops mcas.  On the shelf at Walmart.  Also found in Rhinocort.

[TommyGavin 790]

4 hours ago, TBayXXXVII said:

A real shame he passed away.  He was hilarious.

[Asian voice] You go now - you here 4 hour [/Asian voice]

[TommyGavin 790]

5 hours ago, Pimpadeaux said:

Nyquil is the bomb. 

Not a fan. Knocks you out quick but it’s not long lasting. I usually wake up groggy in 3 to 4 hours and can’t go back to sleep

[Cruzer 1,995]

I hate Nyquil... Oh it will put me to sleep alright, but it lingers and makes me drowsy AF all the next day too. 

[TommyGavin 790]

10 minutes ago, Cruzer said:

I hate Nyquil... Oh it will put me to sleep alright, but it lingers and makes me drowsy AF all the next day too. 

See above. Said same thing. I can drink a pint  and a half of JD and be fine next day but 2 ounces of NyQuil ruins my next day. 

[Hardcore troubadour 14,926]

Purple drank. Syzrup. 

[Mookz 1,337]

11 minutes ago, Hardcore troubadour said:

Purple drank. Syzrup. 

 

[Gepetto 1,288]

Don't be so gullible and believe everything you read in the year 2023. These medicines do work.